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COMMENT The paper by Wilson et al. is extremely timely and important. It attributes a key role to myeloid cells in coping with aging in general, and age-related neurodegenerative diseases in particular, with an emphasis on Alzheimer’s disease, focusing on trigger
COMMENT Over the last 20 years, it became evident that adaptive and innate immune cells play a key role in lifelong brain plasticity and protection in health, with far-reaching implications for brain aging and diseases. This transformative understanding raised qu
COMMENT This paper emphasizes once again a paradigm that is becoming increasing clear: different forms of dementia, including Alzheimer’s disease, are not diseases of only the brain, but also involve the immune system and the immune-brain axis. The present study
COMMENT This manuscript provides a new insight to the mechanism underlying the contribution to Alzheimer’s disease of the MS4A locus, which distinguishes between protective and destructive microglia. It also highlights the connection between cholesterol metabolis
COMMENT The role of the immune system in shaping the brain’s fate in health, aging, and disease has received significant attention over the last two decades (Croese et al., 2021). Yet, understanding the detailed pathology of these diseases is still in its infancy
COMMENT In this study, the authors attribute an important protective role to self-reactive T cells and speculate that the T cell facilitates early clearance of toxic aggregated tau seeds, either by recruiting β cells and generating an antibody response targeting
COMMENT Selectivity of neuronal loss under disease conditions is still a mystery. In the present study, Zalocusky and colleagues attribute a key role to neuronal expression of APOE in regulating MHC-I expression, and thereby, selective neuronal vulnerability. Thi
COMMENT For decades, cognitive deterioration occurring during aging was considered to be neuronal-centric, and thus was attributed solely to neuron exhaustion, dysfunction, or, in the extreme case, to neuronal loss. Over the last two decades, emerging studies des
COMMENT Harnessing the peripheral immune system as a neuroprotective therapeutic approach to Alzheimer's disease: Discussion regarding pathways and mechanism Immunotherapy targeting the programmed death protein (PD)-1/PD-L1 pathway was shown to be effective
COMMENT With regard to Latta-Mahieu et al., 2018, I am confident that the three groups that published this paper would have been able to repeat the positive effect of anti-PD-1 antibody on plaque burden, if they had calibrated the antibody and the treatment proto
COMMENT Suzzi and Afroditi Tsitsou-Kampeli are co-authors of this comment michal.schwartz 0 Aging-induced type
COMMENT We thank Richard Ransohoff for his insightful comments. We would like to clarify several points:
COMMENT This paper by Cooper-Knock and colleagues describes an extremely important study in understanding ALS, and in searching for prognostic biomarkers of ALS progression. Overall, the work emphasizes that ALS, not only in animal models but also in patients, is
COMMENT In this elegant and important study, Samuel E. Marsh and colleagues demonstrate that deficiency in the adaptive arm of the immune system exacerbates pathology in an Alzheimer’s disease mouse model. While the hypothesis that adaptive immunity plays a role
COMMENT It is becoming increasingly clear that circulating immune cells play a role in Alzheimer’s disease (AD) pathophysiology. These cells can play a direct role in affecting the local neuroinflammatory process associated with AD, as well an indirect role via t
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